The Effects of Dietary Erythritol on Platelet Reactivity and Vascular Inflammation
Recruiting now · Not applicable
Conditions studied: Platelet Aggregation, Spontaneous, Vascular Thrombosis
In brief
The purpose is to conduct a dietary intervention study in which human participants will consume beverages sweetened with erythritol or aspartame, each for 2 weeks, in a randomized crossover design
Key facts
- Study ID
- NCT05967741
- Run by
- University of California, Davis
- People needed
- 24
- Starts
- 2023-07-20
- Expected to finish
- 2026-06-01
- Last updated by the study team
- 2025-12-05
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- BMI ≥ 27 kg/m2
You may not qualify if…
- • History of blood clot, transient ischemic attack (TIA), stroke, angina, heart attack, or peripheral vascular disease, or current cancer diagnosis.
- Pregnant or lactating women
- Current, prior (within 12 months), or anticipated use of medications for treatment of hyperlipidemia, high blood pressure or diabetes, or any medication that in the opinion of the investigators will confound results.
- Unwilling to forego the use of anti-inflammatory medication during study.
- Unwilling to forego the use of marijuana during the study.
- Use of tobacco.
- Strenuous exerciser (>4 hours/week at a level more vigorous than walking).
- Surgery or medication for weight loss.
- Diet exclusions: Food allergies or dietary restrictions that may undermine compliance to dietary protocol, routine ingestion of more than 2 sugar-sweetened beverages or 2 alcoholic beverage/day. Unwillingness to consume artificial or noncaloric sweeteners. Habitual consumption (>10 gram/day) of beverage or foods that contain erythritol. Recent or current weight loss diet.
Where it is running
- Ragle Human Nutrition Research Center, University of California, Davis — Davis, California, United States (enrolling)
Full record on ClinicalTrials.gov
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