Optimizing Phototesting and Investigating Photobiology of Visible Light

Running, not enrolling · Not applicable

Conditions studied: Healthy

In brief

Specific Aim 1: To determine the impact of spectral composition of the VL+UVA1 source on the associated biologic effects. Specific Aim 2: To investigate differential responses of subjects with different skin phototypes to VL+UVA1, including immediate and delayed erythema and pigmentation, and photodamage.

Key facts

Study ID

NCT05964907

Run by

Henry Ford Health System

People needed

14

Starts

2021-10-06

Expected to finish

2026-12-30

Last updated by the study team

2026-05-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy individuals age 18 and older
• Fitzpatrick skin phototype (SPT) I-VI, 7 with SPT I-III and 7 with SPT IV-VI, with normal healthy skin
• Able to understand the requirements of the study and its associated risks
• Able to complete and sign a consent form
• Willing and able to refrain from any medications or herbal supplements during the duration of the study, unless permitted by the investigator
• Agrees to refrain from using any new topical skin care products, laundry detergents, or fragrances while participating in the study
• Has not had excessive sun exposure for 7 days prior to enrollment in the study

You may not qualify if…

• Recent history of vitiligo, melasma, and other disorders of pigmentation with the exception of post-inflammatory hyperpigmentation
• History of relevant skin conditions such as atopic dermatitis, eczema, or sunburn on any part of the body
• History of photodermatoses or photosensitivity disorders
• History of melanoma or non-melanoma skin cancers
• Use of tanning parlors or exposure of the irradiated sites to sun light during the duration of the study
• Use of topical or systemic treatment that is likely to interfere with assessment, study results, or pose safety concerns
• Subjects with a tendency to bleed excessively
• Known allergies to anesthetics (lidocaine) or anaphylaxis treatment (epinephrine)
• History of hypertrophic scarring or keloid formation
• Use of any photosensitizing medication within the visible light range or additional medication at the discretion of the investigator [examples include - but not limited to - thiazide diuretics, regular use of NSAIDs, hydroxychloroquine, or voriconazole
• A woman who is lactating, pregnant, or planning to become pregnant

Where it is running

• Henry Ford Medical Center — Detroit, Michigan, United States

Full record on ClinicalTrials.gov

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