Efficacy of Liposomal Bupivacaine Post Septorhinoplasty

Enrolling by invitation · Phase 3 · Has a placebo group

Conditions studied: Rhinoplasty, Pain Management

In brief

The objective of this study is to determine if there is a difference in post-operative pain after septorhinoplasty when long-acting liposomal bupivacaine is used for local anesthesia compared to other standard local anesthetic regimens.

Key facts

Study ID

NCT05964868

Run by

Jessyka Lighthall

People needed

72

Starts

2024-02-05

Expected to finish

2027-07-01

Last updated by the study team

2026-04-03

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subject must be undergoing rhinoplasty or septorhinoplasty surgery
• Male or female subjects greater than or equal to 18 years of age
• Written informed consent must be obtained

You may not qualify if…

• The subject is a pregnant or lactating 3. Patients have a cognitive impairment 4. Patient is a prisoner 5. Patients with hypersensitivity to local anesthetics and pain medications used in the study 6. Patients weighing less than 48 kg 7. Patients preoperatively taking narcotics for chronic pain 8. Patients with pre-existing painful conditions (complex regional pain syndrome, fibromyalgia, neuropathy) 9. Patients with liver dysfunction 10. Patients with increased creatinine (over 1.5 mg/dl) 11. Patients who have undergone autologous costal cartilage grafting with their rhinoplasty 12. Morbid obesity (BMI >40)

Where it is running

• Jessyka Lighthall — Hershey, Pennsylvania, United States

Full record on ClinicalTrials.gov

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