Feasibility of Individualized, Model-guided Optimization of Proton Beam Treatment Planning in Patients With Low Grade Glioma

Recruiting now · Phase 2

Conditions studied: Low Grade Glioma

In brief

Low-grade glioma (LGG) represent typically slowly growing primary brain tumors with world health organization (WHO) grade I or II who affect young adults around their fourth decade. Radiological feature on MRI is a predominantly T2 hyperintense signal, LGG show typically no contrast uptake. Radiotherapy plays an important role in the treatment of LGG. However, not least because of the good prognosis with long term survivorship the timing of radiotherapy has been discussed controversially. In order to avoid long term sequelae such as neurocognitive impairment, malignant transformation or secondary neoplasms initiation was often postponed as long as possible

Key facts

Study ID

NCT05964569

Run by

University Hospital Heidelberg

People needed

120

Starts

2023-11-11

Expected to finish

2028-11-11

Last updated by the study team

2024-01-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > 18 years
• histologically proven low-grade glioma
• indication for definitive or adjuvant radiotherapy
• ability to understand character and personal consequences of the clinical trial
• written informed consent

You may not qualify if…

• previous cerebral irradiation
• contraindication for contrast-enhanced MRI
• neurofibromatosis
• participation in another clinical trial with competing objectives

Where it is running

• Department of Radiotherapy, University of Heidelberg — Heidelberg, Germany (enrolling)

Full record on ClinicalTrials.gov

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