Fetuin A as a Predictor of Deterioration of Renal Function in Hypertonic Patients

Recruiting now

Conditions studied: Arterial Hypertension

In brief

Commonly used parameters (creatinine, estimated glomerular filtration rate, and urine albumin/creatinine ratio) for prediction of decline of renal function are sensitive for advanced kidney impairment. Modified human urine Fetuin A (urine Fetuin A) with specific modification in urine (Fetuin A) can earlier predict the progression of kidney disease in patients with diabetes. Studies evaluating urine Fetuin A in hypertonic patients are still lacking.

Key facts

Study ID

NCT05963126

Run by

University Hospital Ostrava

People needed

200

Starts

2023-07-01

Expected to finish

2026-12-31

Last updated by the study team

2023-07-27

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Arterial hypertension treated by at least one antihypertensive agent

You may not qualify if…

• Diabetes mellitus of any type, defined as fasting glucose >7,0 mmol/l or any glycemia >11,0 mmol/l, or HbA1c>48 mmol/mol
• Decompensated arterial hypertension defined as office blood pressure >180/110 mmHg or on Ambulatory Blood Pressure Monitoring (ABPM)
• Patient with renal replacement therapy
• Present rheumatoid disease (rheumatoid arthritis, systemic lupus, sclerodermia, dermatomyositis, Inflammatory Bowel Disease, etc.), positivity of antinuclear antibody (ANA) / extractable nuclear antigen (ENA) screening
• Acute infection defined as C-Reactive Protein (CRP) >50 mg/l
• Severe impairment of liver function defined as cirrhosis, Alanine Transaminase or ASpartate Transferase (ALT or AST) >10 µkat/l
• Terminal incurable illness

Where it is running

• University Hospital Ostrava, - Department of Internal Medicine and Cardiology — Ostrava, Czech Republic, Czechia (enrolling)

Full record on ClinicalTrials.gov

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