Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine

Recruiting now · Phase 1

Conditions studied: Nicotine Dependence, Nicotine Vaping

In brief

In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.

Key facts

Study ID

NCT05962229

Run by

University of California, San Francisco

People needed

18

Starts

2024-12-06

Expected to finish

2027-05-01

Last updated by the study team

2026-05-14

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy on the basis of medical history and limited physical examination.
• Current regular user of E-Cigarettes (≥ 15 days in the past 30 days)

You may not qualify if…

• • Medications
• Use of medications that are inducers of nicotine metabolizing enzyme CYP2A6 (Example: rifampicin, carbamazepine, phenobarbital, and other anticonvulsant drugs).
• Use of sympatholytic medications for cardiovascular conditions including hypertension (Example: beta and alpha-blockers).
• Concurrent use of nicotine-containing medications (Example: nicotine patch, lozenge, gum).
• Any stimulant medications (example: Adderall) generally given for ADHD treatment.
• Pregnancy
• Pregnancy (self-reported and urine pregnancy test)
• Breastfeeding (determined by self-report)
• Women of childbearing potential must be using an acceptable method of contraception
• Inability to read and write in English
• A known propylene glycol/vegetable glycerin allergy
• Uncomfortable with getting blood drawn

Where it is running

• Zuckerberg San Francisco General Hospital (ZSFG) — San Francisco, California, United States (enrolling)

Full record on ClinicalTrials.gov

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