Thromboxane Function in Women With Endometriosis
Completed · Phase 4 · Has a placebo group
Conditions studied: Endometriosis
In brief
The goal of this clinical trial is to compare neurovascular regulation in women with endometriosis and healthy women. The main questions it aims to answer are: * Do women with endometriosis have greater blood pressure and pain responses to a stimulus than healthy women? * Do women with endometriosis have greater platelet activity than healthy women? Participants will take aspirin and/or placebo and will: * perform hand grip exercise and cold pressor tests * undergo iontophoresis and blood draw Researchers will compare women with and without endometriosis to see if there is a difference in neurovascular regulation.
Key facts
- Study ID
- NCT05962034
- Run by
- Penn State University
- People needed
- 21
- Starts
- 2024-01-01
- Expected to finish
- 2026-07-23
- Last updated by the study team
- 2026-07-27
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Born with a uterus
- 18-45 years old
- With and without endometriosis
You may not qualify if…
- Currently pregnant or breastfeeding
- Diagnosed cardiovascular disease
- BMI over 35
- Nicotine use (e.g., smoking, chewing tobacco, vaping, etc.)
- Currently using hormone replacement therapy (or have used within previous 6 months)
- Known skin allergies or current rash, skin disease, disorders of pigmentation
- Diabetes
- Renal disease, renal artery stenosis, renal impairment
- Liver disease
- Stage II Hypertension (blood pressure >140/>90 mmHg)
- Hypotension (blood pressure < 90/60 mmHg)
- Raynaud's syndrome
- Any current medications which could conceivably alter cardiovascular responses (e.g. antihypertension medication, diuretic, digoxin)
- Allergy or hypersensitivity to investigational agents
- Immunosuppressed/immunocompromised
Where it is running
- Noll Laboratory — University Park, Pennsylvania, United States
Full record on ClinicalTrials.gov
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