Change in Inflammatory State in Patients Undergoing Transcatheter Ablation of Atrial Fibrillation

Recruiting now

Conditions studied: Atrial Fibrillation, Marker of Inflammation, Inflammation, Arrhythmia

In brief

It is a non-pharmacological (biological), spontaneous observational study. The main objective is to evaluate the correlation between inflammation markers and local adiposity, clinical risk factors and their possible variation following an AF ablation procedure

Key facts

Study ID

NCT05961865

Run by

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

People needed

180

Starts

2023-07-11

Expected to finish

2027-08-01

Last updated by the study team

2023-09-13

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Paroxysmal or persistent AF;
• Patients undergoing ESC/ERAH(European Society of Cardiology/European Heart Rhythm Association) approved catheter ablation procedures;
• Aged between 18 and 85 years;
• Ability to provide informed consent for study participation.

You may not qualify if…

• Age > 85 years or < 18 years;
• Presence of left auricular thrombosis on pre-procedural transesophageal echocardiogram;
• NYHA functional class IV;
• Left ventricular ejection fraction <30%;
• Myocardial infarction or unstable angina or recent coronary artery bypass graft (<6 months);
• Significant co-morbidity, such as cancer, severe renal failure requiring dialysis, severe obstructive pulmonary disease, cirrhosis, with a life expectancy of less than 12 months;
• Presence of contraindications to the procedure;
• Inability to provide informed consent for study participation.

Where it is running

• Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico — Milan, Italy (enrolling)

Full record on ClinicalTrials.gov

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