NM Balance Regulation With ULLS and Loss of Sleep

Completed · Not applicable

Conditions studied: Muscle Weakness, Quadriceps Muscle Atrophy, Sleep Disturbance

In brief

The goal of this trial is to learn about how restricted sleep and not bearing weight on the leg affects muscle strength and posture control. Participants will walk exclusively on one leg, sleep at differing intervals, and complete posture tests, muscle strength tests, and muscle imaging. Researchers will compare adequate sleep and restricted sleep to see if muscle strength and posture are affected.

Key facts

Study ID

NCT05956964

Run by

Lance Bollinger

People needed

16

Starts

2023-08-10

Expected to finish

2025-03-14

Last updated by the study team

2026-06-17

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age between 18 and 50 years
• Regularly engaging in aerobic exercise (> 150min/wk) and resistance exercise (>1 time per week) for the past 12 months
• Regularly sleep at least 7 hours per night

You may not qualify if…

• Age < 18 or > 50 years
• Height between <150 (F) or <170 (M) and > 190 cm (both sexes)
• Waist circumference < 55cm or > 90cm (F) and < 75cm or > 100cm (M)
• Body mass index < 18.5 or > 27.5
• Do not regularly sleep between 7 and 9 hours each night
• Have a known sleep disorder
• Not regularly engaging in exercise for previous 12 months
• Blood clotting disorder
• Heart arrhythmia
• Implanted device which could negatively be affected by electrical impulse or strong magnetic field such as pacemaker, internal defibrillator, or cochlear implant
• Diagnosed cardiovascular, pulmonary, renal, or metabolic disease
• Pregnancy (within previous 6 months)
• Oral contraceptive use (within previous three months)
• High resting blood pressure (>140 systolic and/or > 90 diastolic)
• Currently or previously undergone gender-affirming therapy (hormone therapy or sexual reassignment surgery)
• Low back or leg injury in previous 6 months
• Currently taking medication to assist with sleep
• Muscle, bone, or joint injury that limits physical activity within previous 6 months
• Neurological disorder which affects balance (such as multiple sclerosis or Parkinson's disease)

Where it is running

• University of Kentucky — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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