Sex and Gender-based Analysis of the Effectiveness of Advanced Therapies in Psoriatic Arthritis
Recruiting now
Conditions studied: Psoriatic Arthritis
In brief
Sex and gender are important factors that influence treatment response in PsA. The goal of this multi-centre observational study is to understand how sex and gender influence response to advanced therapies in psoriatic arthritis (PsA). The investigators hope to discover biological and socio-cultural mechanisms that explain the differences in treatment response between men and women with PsA. The study investigators plan to recruit patients from approximately 30 sites across the world. Men and women with active PsA will be assessed before and after they start advanced therapies and information will be collected about sex- and gender-related factors through questionnaires and physical examination. Physicians will assess the patient response to treatment. The investigators will compare the response to treatment in men and women and assess what biological and socio-cultural factors contribute to differences in treatment response.
Key facts
- Study ID
- NCT05954364
- Run by
- Women's College Hospital
- People needed
- 540
- Starts
- 2023-01-23
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2023-07-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Rheumatologist confirmed diagnosis of PsA according to CASPAR criteria
- Age ≥18 years
- Active PsA with any of the following manifestations detected on physical examination: peripheral arthritis, dactylitis, and enthesitis. The patient may have axial involvement in addition to the peripheral manifestations of PsA
- Plan to start treatment with advanced therapies for peripheral musculoskeletal manifestations of PsA
You may not qualify if…
- Unable to read or write
- Unable to sign informed consent
- Cannot return for a follow up visit
- The drug is given for another indication and not for active PsA (e.g. psoriasis, IBD)
- Pregnant women
Where it is running
- Women's College Hospital — Toronto, Ontario, Canada (enrolling)
Full record on ClinicalTrials.gov
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