Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With DLBCL

Recruiting now · Phase 2

Conditions studied: Diffuse Large B-Cell Lymphoma

In brief

The study will measure the safety, tolerability, and efficacy with acalabrutinib in combination with rituximab in treatment-naïve elderly and/or frail patients with diffuse large B-cell lymphoma (DLBCL), who are otherwise unsuitable for standard front line chemoimmunotherapy treatments.

Key facts

Study ID: NCT05952024
Run by: AstraZeneca
People needed: 80
Starts: 2024-07-16
Expected to finish: 2029-04-22
Last updated by the study team: 2026-08-06

Who can join

Age: 65 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

≥ 80 years of age at the time of screening, or
≥ 65 to 79 years of age at the time of screening and considered ineligible for chemoimmunotherapy
Histologically documented DLBCL
No prior treatment for DLBCL
Stage II, III, or IV disease by the Ann Arbor Classification .
Eastern Cooperative Oncology Group performance status of 0, 1, or 2 with no deterioration over the previous 2 weeks prior to baseline or day of the first dosing except when due to underlying lymphoma.
At least 1 lesion that can be accurately measured at baseline as ≥ 10 mm in the longest diameter with computed tomography or magnetic resonance imaging and is suitable for accurate repeated measurements.
Adequate organ and marrow function independent of growth factor or transfusion support within 1 week of Screening.

You may not qualify if…

Any evidence of diseases (such as severe or uncontrolled systemic diseases, including uncontrolled hypertension, renal transplant, and active bleeding diseases), that would make the study undesirable for the patient or that would impact compliance with the protocol.
History of prior or current malignancy, that would affect compliance with the protocol or interpretation of the results.
Serologic status reflecting active hepatitis B or C infection.
Serological positivity or known infection with HIV.
Active central nervous system involvement by lymphoma, leptomeningeal disease, or spinal cord compression.
Any comorbidity or organ system impairment rated with a single Cumulative Illness Rating Scale-Geriatric score (CIRS-G) of 4 or a total CIRS-G score of > 17.
History of or ongoing confirmed Progressive Multifocal Leukoencephalopathy.
Known active significant infection.
History of stroke or intracranial haemorrhage within 6 months before the first dose of study drug.
History of bleeding diathesis (eg, haemophilia, von Willebrand disease).
Major surgical procedure within 30 days of first dose of study intervention or anticipated major surgery during the study timeframe.
Requires or receiving anticoagulation with warfarin or equivalent vitamin K antagonists.
Received a live virus vaccination within 28 days of the first dose of study drug.

Where it is running

Research Site — Busan, South Korea (enrolling)
Research Site — Des Moines, Iowa, United States (enrolling)
Research Site — Brasília, Brazil (enrolling)
Research Site — Tacoma, Washington, United States (enrolling)
Research Site — Seoul, South Korea (enrolling)
Research Site — Florianópolis, Brazil (enrolling)
Research Site — Lexington, Kentucky, United States
Research Site — Lubbock, Texas, United States
Research Site — Orange, California, United States
Research Site — Sioux Falls, South Dakota, United States
Research Site — Goiânia, Brazil
Research Site — Olympia, Washington, United States
Research Site — Detroit, Michigan, United States
Research Site — Barretos, Brazil
Research Site — Jacksonville, Florida, United States
Research Site — Brasília, Brazil
Research Site — Towson, Maryland, United States
Research Site — Brasília, Brazil
Research Site — Campinas, Brazil
Research Site — Curitiba, Brazil
Research Site — Florianópolis, Brazil
Research Site — Belo Horizonte, Brazil
Research Site — Beltsville, Maryland, United States
Research Site — Natal, Brazil
Research Site — Stamford, Connecticut, United States

Full record on ClinicalTrials.gov

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