Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0

Recruiting now · Not applicable

Conditions studied: Dementia, Alzheimer Disease, Infections

In brief

The goal of this pragmatic cluster randomized clinical trial is to compare management of suspected infection in nursing home residents with dementia The main questions it aims to answer whether residents with dementia in nursing homes randomized to use a multicomponent intervention to optimize suspected infection management ( versus usual care) use less antibiotics and fewer burdensome interventions.

Key facts

Study ID

NCT05950607

Run by

Hebrew SeniorLife

People needed

750

Starts

2023-11-13

Expected to finish

2026-06-30

Last updated by the study team

2026-01-06

Who can join

Age: 60 and older, up to 106. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > 60
• A diagnosis of dementia (any type)
• Cognitive Functional Scale (CFS) > 1
• NH length of stay >90 days
• The CFS score categorizes cognitive impairment status based on data in the electronic health record into: 1. None, 2. Mild, 3. Moderate, and 4. Severe (advanced). For the primary outcome, the analysis will be restricted to residents with a CFS score of 3 or 4.

You may not qualify if…

• Less than 60 years of age
• Living in nursing home for less than 90 days
• Does not have diagnosis of dementia
• Does not meet CFS >1 score

Where it is running

• Hebrew SeniorLife — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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