Effect of Metformin, a Drug Used to Treat Diabetes, vs Placebo

Running, not enrolling · Phase 4 · Has a placebo group

Conditions studied: NIDDM, Obesity

In brief

Metformin is a drug used to treat patients with diabetes. The aim of this study is to examine the effect of Metformin along with a low-calorie diet on obese and/or overweight adults with an increased waist measurement. In addition, the study also aims to look at the effect of the drug vs. placebo on quality of life and physical activity.

Key facts

Study ID

NCT05949008

Run by

University of California, Los Angeles

People needed

150

Starts

2023-11-22

Expected to finish

2028-07-30

Last updated by the study team

2026-06-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or female, age ≥ 18 years at the time of signing informed consent.
• Body Mass Index (BMI) ≥ 27 kg/m2
• Waist circumference >40" for men, and >35" for women

You may not qualify if…

• A self-reported change in body weight > 5 kg (11 lbs) within 90 days before screening irrespective of medical records
• Diagnosed with T2D (HbA1c >7.5 (53 mmol/mol)
• Current use of insulin or oral medication of metformin, SU, SGLT2i, glitazone, DPP4 or GLP-1 agonist injections as single agent therapy or combination oral agents.
• Renal impairment measured as estimated Glomerular Filtration Rate (eGFR) value of < 45 mL/min/1.73 m2 (< 60 ml/min/1.73 m2 in subjects treated with SGLT2i) according to CKDEPI creatinine equation as defined by KDIGO 201242 by the central laboratory at screening
• History of thyroid disease, but not taking medication or medication dosage changed one or more times over last 6 months (History of thyroid disease and on a stable dose of prescription medication for 6 months or longer is acceptable).
• History or lactic acidosis
• Liver problems
• Congestive heart failure
• History of alcoholism
• Recent surgery
• Heart attack, severe infection or stroke
• Any unstable medical conditions or terminal diagnosis
• Pregnancy or lactation
• Allergy and intolerance to metformin

Where it is running

• UCLA Center for Human Nutrition — Los Angeles, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.