Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy Young Individuals

Completed · Not applicable

Conditions studied: Dietary Supplementation

In brief

The aim of this study was to determine whether grape seed extract (GSE) supplementation could reduce the blood pressure (BP) in response to static exercise and post exercise muscular ischemia (PEMI) in normotensive young adults. In 12 healthy subjects (7 male and 5 female, 24.6±3.4 yr), we compared acute effect of both GSE (600 mg) and placebo (PL: 600 mg) on changes from rest in systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) during static exercise (SE) and PEMI. Subjects completed 2 min of SE at 30% of maximal voluntary contraction (MVC) followed by 2 min of PEMI.

Key facts

Study ID

NCT05945771

Run by

California Baptist University

People needed

12

Starts

2022-05-01

Expected to finish

2022-08-31

Last updated by the study team

2023-07-14

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy volunteers (SBP < 120 mmHg, DBP < 80 mmHg)

You may not qualify if…

• cardiovascular and/or pulmonary disease,
• musculoskeletal disorders
• medications that prevent the safe completion of the exercise protocol

Where it is running

• California Baptist University — Riverside, California, United States

Full record on ClinicalTrials.gov

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