Continuation Of a Study to Investigate the Effect of Thoracocentesis on Neural Respiratory Drive in Pleural Effusion

Recruiting now

Conditions studied: Pleural Effusion

In brief

The aim of this study is to better understand the relationship between pleural effusions and breathlessness in patients with unilateral pleural effusions and breathlessness who require pleural fluid removal for its management.

Key facts

Study ID

NCT05945043

Run by

Guy's and St Thomas' NHS Foundation Trust

People needed

124

Starts

2023-11-15

Expected to finish

2027-06-30

Last updated by the study team

2026-06-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or above
• Has a unilateral pleural effusion AND
• require thoracocentesis OR
• chest drain insertion (main study only) OR
• has an IPC in situ (main study only)

You may not qualify if…

• Inability to consent
• Any contraindications to the proposed pleural procedure
• Haemodynamic or clinical instability that precludes from the safe completion of required pre-procedural measurements
• Inability to identify surface landmarks for surface EMG electrode placement
• Past medical history of diaphragmatic paralysis (diaphragm sub study only)

Where it is running

• Guy's & St Thomas' NHS Foundation Trust — London, London, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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