Low-dose Versus a High-dose Sublingual Buprenorphine Induction

Running, not enrolling · Phase 4

Conditions studied: Opioid Use Disorder

In brief

This study proposes to compare a low-dose versus a high-dose buprenorphine induction scheme in 40 fentanyl using people with Opioid Use Disorder (OUD). Study participants will be randomized to either the low-dose (n=20) or high dose (n=20) group and dispensed medication daily for one week.

Key facts

Study ID

NCT05944952

Run by

Friends Research Institute, Inc.

People needed

40

Starts

2024-06-20

Expected to finish

2025-10-30

Last updated by the study team

2025-08-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult male or female (≥ 18 years of age) persons with a DSM-5 diagnosis of OUD;
• Must have a fentanyl positive urine test;
• Able to come to the clinic every day for the first week of treatment.

You may not qualify if…

• No exclusionary medical history or mental health issues as determined by the admitting provider; e.g., patients with untreated or unstable serious mental illness, including psychotic disorders;
• Alcohol withdrawal requiring pharmacological management;
• Urine positive for buprenorphine, benzodiazepines, or methadone; 4. Enrolled in a methadone treatment program in the past 14 days; 5. Inability to pass a study enrollment quiz.

Where it is running

• MATClinics — Dundalk, Maryland, United States

Full record on ClinicalTrials.gov

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