ASPIRE Health Tulare County

Status unconfirmed · Not applicable · Has a placebo group

Conditions studied: Respiratory Tract Diseases, Cardiovascular Diseases

In brief

The goal of this clinical trial is to compare indoor air quality and health in people exposed to air pollution, including possible exposure to wildfire smoke. The study will test the effect of using a do-it-yourself (DIY) air cleaner when air pollution is present to answer the following questions: * Do health outcomes differ between participants who use a DIY PAC and those who use a sham air cleaner? * How effective is the DIY air cleaner in reducing indoor concentrations of fine particles (PM2.5), and volatile organic compounds found in wildfire smoke? OR How effective is the DIY air cleaner in reducing indoor concentrations of fine and coarse particles (i.e., PM 10)? * What are barriers to use of a DIY air cleaner and what factors facilitate its use? Participants will be asked to do the following: * Participate in 5 home visits from study staff between July - October 2023 * Have an air quality sensor placed in the participant's bedroom for the whole study period * Have a small sensor attached to the main door of the participant's house to record when the door is open or closed (important for air quality inside) * Allow researchers to take air and dust samples in the participant's bedroom * Run a DIY air cleaner in the participant's bedroom for at least 6 nights while the participant sleeps * Complete 2 interviews * Allow study staff to collect 3 fingerstick blood samples * Allow study staff to collect 3 samples of fluid from inside the nose * Use the study air cleaner in the participant's bedroom during the study period The investigators will measure air quality in participating homes and measure health outcomes for participants. The investigators will compare outcomes of participants who use a DIY air cleaner with filters that work well to those of participants who use a DIY air cleaner with a placebo filter (one that does not work well to remove the air pollutants of concern). The goal of the study is to see if using the effective air cleaner leads to better health outcomes and indoor air quality.

Key facts

Study ID

NCT05944770

Run by

Environmental Protection Agency (EPA)

People needed

80

Starts

2023-07-29

Expected to finish

2023-10-31

Last updated by the study team

2023-10-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18 years or older
• Has access to telephone and/or the internet for study communication
• Is a resident of Tulare County, California
• Is proficient in English or Spanish for study communication

You may not qualify if…

• Anyone in the household smokes (tobacco, vape, or other) inside the home
• Plans to move before November 2023
• Regularly travels or sleeps away from home (e.g., once a week or more)
• Already owns and uses a portable air cleaner
• Lives in a multi-unit home with a shared central HVAC system
• Has a bleeding disorder, such as hemophilia (taking a blood thinning medication does not exclude)
• Takes any of the following anti-inflammatory medications regularly: abatacept (Orencia), adalimumab(Humira), anakinra (Kineret), anifrolumab (Saphnelo), apremilast (Otezla), azathioprine (Imuran),certolizumab pegol (Cimzia), etanercept (Enbrel), golimumab (Simponi Aria), hydroxychloroquine(Plaquenil), infliximab (Remicade), ixekizumab (Taltz), leflunomide (Arava), methotrexate(Rheumatrex, Trexall), prednisone (Deltasone), sulfasalazine (Azulfidine), rituximab (Rituxan,MabThera), sarilumab (Kevzara), tocilizumab (Actemra)

Where it is running

• Central California Environmental Justice Network — Fresno, California, United States

Full record on ClinicalTrials.gov

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