Effects of Flumazenil on Recovery After Total Intravenous Anesthesia With Remimazolam

Recruiting now · Not applicable

Conditions studied: Flumazenil Adverse Reaction, Remimazolam, Hip Joint, Elderly Patients

In brief

Remimazolam is a medication that has the advantage of a short half-life and reversibility with flumazenil. In clinical situations, the use of flumazenil for the reversal of sedation is common, but there is no precise indication for its administration. In this study, we aim to investigate the necessity of routine flumazenil use after administering remimazolam for intravenous anesthesia.

Key facts

Study ID: NCT05939674
Run by: Pusan National University Yangsan Hospital
People needed: 24
Starts: 2023-09-19
Expected to finish: 2026-06-01
Last updated by the study team: 2025-09-12

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients over 65 years old scheduled for hip joint surgery

You may not qualify if…

Patients with impaired consciousness or delirium before surgery
Patients who are hemodynamically unstable before surgery
Patients with a history of neurological or neuromuscular disorders or use of medications that affect neurological or neuromuscular function
Patients who have taken sedatives (anti-anxiety medications, antipsychotics, antidepressants, sleep aids) within the past 24 hours
Patients with known allergy to benzodiazepine, flumazenil
Patients with galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption
Patients with hypersensitivity to Dextran40
Patients who have been taking benzodiazepine for long term
Patients with end stage renal disease requiring hemodialysis
Patients with history of acute angle glaucoma
Patients with alcohol or substance dependence
ASA classification 4 or 5

Where it is running

Pusan National University Yangsan Hospital — Yangsan, Gyeongsangnam-do, South Korea (enrolling)

Full record on ClinicalTrials.gov

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