Cerebellar TMS and Satiety in Prader-Willi Syndrome

Recruiting now · Not applicable

Conditions studied: Prader-Willi Syndrome

In brief

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study hyperphagia and satiety in Prader-Willi syndrome. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about how TMS might improve hyperphagia in Prader-Willi syndrome.

Key facts

Study ID

NCT05938543

Run by

Brigham and Women's Hospital

People needed

20

Starts

2023-09-01

Expected to finish

2026-10-01

Last updated by the study team

2025-12-05

Who can join

Age: 18 and older, up to 64. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of Prader-Willi syndrome

You may not qualify if…

• contraindications for TMS or MRI including :
• history of neurological disorder
• history of head trauma resulting in loss of consciousness
• history of seizures or diagnosis of epilepsy or first degree relative family history of epilepsy
• metal in brain or skull
• implanted devices such as a pacemaker, medication pump, nerve stimulator or ventriculoperitoneal shunt claustrophobic in MRI

Where it is running

• McLean Hospital — Belmont, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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