Impact of Respiratory Training in Lymphoma Survivors

Stopped early · Not applicable · Has a placebo group

Conditions studied: Hodgkin Lymphoma, Non Hodgkin Lymphoma

In brief

High-resistance inspiratory muscle strength training (IMST) is a time-efficient (\~5 minutes/day) form of exercise that employs an affordable, handheld device which impedes inspiratory breathing to train the diaphragm and accessory respiratory muscles and has demonstrated improvements in both cardiovascular health (9 mmHg reduction in systolic blood pressure, 45% improvement in vascular endothelial function) and improve exercise tolerance (12% increase in treadmill exercise time) in generally healthy midlife/older adults. Therefore, this approach may circumvent preventative hurdles to exercise, and augment the effects of exercise for capable survivors.

Key facts

Study ID

NCT05938127

Run by

University of Colorado, Denver

People needed

1

Starts

2024-09-16

Expected to finish

2024-12-09

Last updated by the study team

2026-02-27

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 - 80
• Primary cancer diagnosis of lymphoma
• Able and willing to participate in a supervised exercise program at the Anschutz Health and Wellness Center
• Provides a signed physician exercise clearance form
• SBP > 120 mmHg
• Completion of curative cancer treatment over 12 months prior (individuals on maintenance therapy will be included)
• Possession of a smartphone compatible with the IMST training application (available on both Android and Apple).

You may not qualify if…

• oSecond active cancer diagnosis
• oPlanned active cancer treatment or change in current treatment in the next 6 months
• Severe obesity (BMI >; 40 kg/m2) or underweight (BMI <18.5 kg/m2)
• Unstable weight (>; 3 kg change in body mass in last 3 months)
• Significant metabolic disorder (e.g. diabetes type II)
• Uncontrolled thyroid disease
• Recent changes in hypertensive medication (within last 3 months)
• Any medical condition that would impact the safety of, or participation in, an exercise program, including:
• Significant pulmonary conditions such as chronic obstructive pulmonary disease, emphysema, or interstitial lung disease
• Known cardiovascular disease, significant hypertension (>180/120), or a recent cardiac event (within past 6 months)
• Orthopedic conditions such as advanced osteoarthritis, mobility-limiting amputations or chronic injuries, or mobility-limiting acute orthopedic injuries
• Advanced rheumatoid arthritis or chronic widespread pain conditions such as fibromyalgia

Where it is running

• Anschutz Health and Wellness — Aurora, Colorado, United States
• University of Colorado Cancer Center — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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