Prospective, Multi-Center, Observational, Whole Blood Specimen Collection Study in Participants With Rheumatoid Arthritis With Inadequate Response or Intolerance to a DMARD Starting a New bDMARD or tsDMARD Treatment +/- csDMARD

Running, not enrolling

Conditions studied: Rheumatoid Arthritis

In brief

The primary goal of this study is to assess a cfDNA-based blood test using genetic, transcriptomic and/or epigenetic information to help doctors predict the best treatment options for rheumatoid arthritis (RA) patients with inadequate response or intolerance to previous therapies.

Key facts

Study ID

NCT05936970

Run by

Aqtual, Inc.

People needed

1410

Starts

2023-06-29

Expected to finish

2028-06-01

Last updated by the study team

2026-07-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ability to understand and provide written informed consent.
• Male or female ≥18 years of age at enrollment.
• Diagnosis of Rheumatoid Arthritis at the time of enrollment.
• Prior treatment with at least 1 csDMARD, bDMARD, or tsDMARD
• Planning to initiate a new bDMARD (+/- csDMARD) or tsDMARD (+/- csDMARD), within 1 month after enrollment.
• Moderate to high Clinical Disease Activity Index (CDAI) of (>10) with a minimum 4 tender joints and 4 swollen joints at the time of screening.

You may not qualify if…

• Unsuitable for participation in the opinion of the principal investigator.

Where it is running

• Arizona Arthritis & Rheumatology Research — Phoenix, Arizona, United States
• Medvin Clinical Research - Apple Valley — Apple Valley, California, United States
• Medvin Clinical Research - Covina — Covina, California, United States
• Medvin Clinical Research - Riverside — Riverside, California, United States
• Medvin Clinical Research - Tujunga — Tujunga, California, United States
• Medvin Clinical Research - Whittier — Whittier, California, United States
• AARDS Research, Inc — Aventura, Florida, United States
• Highlands Advanced Rheumatology and Arthritis Center (HARAC) — Avon Park, Florida, United States
• Bay Area Rheumatology — Clearwater, Florida, United States
• Believe Clinical Trials — Coral Springs, Florida, United States
• GNP Research — Hollywood, Florida, United States
• Life Clinical Trials — Margate, Florida, United States
• Vitalia Medical Research — Palm Beach Gardens, Florida, United States
• Shine a Light Research — Sun City Center, Florida, United States
• West Broward Rheumatology Associates — Tamarac, Florida, United States
• St. Luke's Clinic — Boise, Idaho, United States
• Arnold Arthritis & Rheumatology — Skokie, Illinois, United States
• Illinois Bone and Joint Institute — Willowbrook, Illinois, United States
• Lake Cumberland Rheumatology — New Albany, Indiana, United States
• Clinical Research Institute of Michigan — Saint Clair Shores, Michigan, United States
• St. Paul Rheumatology — Eagan, Minnesota, United States
• AARA/Kansas City Physician Partners — Kansas City, Missouri, United States
• New England Rheumatology & Osteoporosis — Henniker, New Hampshire, United States
• Arthritis Rheumatism and Bone Disease Associates — Voorhees Township, New Jersey, United States
• Sahni Rheumatology & Therapy — West Long Branch, New Jersey, United States

Full record on ClinicalTrials.gov

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