Phase 2 Study to Evaluate RPT193 in Adults With Moderate to Severe T2-high Asthma

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Asthma

In brief

Randomized, multi-center, double-blind, placebo-controlled, parallel group, proof of-concept study with RPT193 in subjects with T2-high, moderate-to-severe asthma who are partially controlled on medium or high doses of inhaled corticosteroids (ICS) in combination with long-acting beta 2 agonist (LABA).

Key facts

Study ID

NCT05935332

Run by

RAPT Therapeutics, Inc.

People needed

38

Starts

2023-07-05

Expected to finish

2024-06-21

Last updated by the study team

2026-03-23

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Physician diagnosis of asthma for ≥6 months
• Pre-bronchodilator FEV1 of >40% and <80%
• History of treatment with corticosteroid or hospitalization for worsening asthma
• Medium- or high-dose inhaled corticosteroid use

You may not qualify if…

• History of smoking/vaping
• History of severe COVID
• Serious and/or uncontrolled pulmonary, cardiac, immune system conditions
• Requires systemic oral or IV corticosteroids in the month prior to screening

Where it is running

• Allergy and Asthma Associates of Santa Clara Valley Research Center — San Jose, California, United States
• Bensch Clinical Research LLC — Stockton, California, United States
• Allianz Research Institute — Westminster, California, United States
• Allianz Research Institute CO — Aurora, Colorado, United States
• Sonce Medical Research — Miami, Florida, United States
• Coral Research Clinical Corp — Miami, Florida, United States
• San Marcos Research Clinic — Miami Lakes, Florida, United States
• Clinical Research Trials of Florida — Tampa, Florida, United States
• OK Clinical Research LLC — Edmond, Oklahoma, United States
• Velocity Clinical Research Grants Pass — Grants Pass, Oregon, United States
• Western Sky Medical Research — El Paso, Texas, United States
• Metroplex Pulmonary & Sleep Center — McKinney, Texas, United States
• Allergy, Asthma & Sinus Ceneter SC — Greenfield, Wisconsin, United States
• Medical Center "Zadrave-1" — Kozloduy, Bulgaria
• Medical Center Excelsior — Sofia, Bulgaria
• Diagnostic-Consultative Center Convex Ltd. — Sofia, Bulgaria
• University Multiprofile Hospital for Active Treatment — Stara Zagora, Bulgaria
• Medical Center "ResearchExpert" Ltd — Varna, Bulgaria
• Specialized Hospital for Active Treatment of Pneumo-Phthisiatric Diseases - Vratsa — Vratsa, Bulgaria
• MediTrial s.r.o — Jindřichův Hradec, Czechia
• Trialmed Sp z. o.o.o CRS Warszawa — Warsaw, Solipska, Poland
• Centrum Medycyny Oddechowej Mróz Spółka Jawna — Bialystok, Poland
• NZOZ Poradnie Specjalistyczne Atopia — Krakow, Poland
• IP Clinic Sp. z.o.o — Lodz, Poland
• Centrum Diagnostyczno Terapeutyczne MEDICUS Sp. z o.o. - Szpital — Lubin, Poland

Full record on ClinicalTrials.gov

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