Examining the Role of Female Endogenous Sex Hormones in Eccentric Exercise
Recruiting now · Not applicable
Conditions studied: Inflammatory Response
In brief
The fluctuating concentrations of female sex hormones, namely estrogen and progesterone may have an effect on the ability of the tissue to withstand challenging exercise conditions, such as eccentric exercise. These sex hormones have also been purported to influence the perceived difficulty of exercise. This study aims to uncover how the different estrogen and progesterone concentrations present throughout the menstrual cycle effect perceived readiness to perform, perceptions of difficulty, and different recovery metrics.
Key facts
- Study ID
- NCT05934708
- Run by
- University of Southern California
- People needed
- 30
- Starts
- 2025-03-07
- Expected to finish
- 2026-08-01
- Last updated by the study team
- 2026-03-25
Who can join
Age: 18 and older, up to 35. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- 18-35 years of age
- BMI of 18.5-29.9 as a BMI below or above these cut points results in highly varied menstrual cycle lengths [15]
- Not taking contraception or other types of medication that could influence reproductive status
- Regular menstruation
- Non-pregnant
- Medically free from chronic diseases
- Novel to downhill running
- Weight greater than or equal to 110 lbs
- Not taking exogenous hormones
- Not suffering from known gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity
You may not qualify if…
- Amenorrhea or oligomenorrhea
- Perimenopausal or menopausal
- Recreational or professional trail or downhill runner
- On a form of contraception
- Cardiac disability
- Pacemaker
- Arterial disease
- Uncontrolled hemorrhage
- Blood clots
- Pregnant or trying to become pregnant
- Cancerous lesions
- Sensory or mental impairment
- Unstable fractures
- Weight less than 110 lbs
- Suffering from gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity
- Taking exogenous hormones
Where it is running
- Clinical Exercise Research Center — Los Angeles, California, United States (enrolling)
Full record on ClinicalTrials.gov
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