Single and Combined Modality Trans-Oral Robotic Surgery in Early Oropharyngeal Cancer

Recruiting now

Conditions studied: Cancer Head Neck

In brief

Multi-centre retrospective observational cohort study with optional exploratory radiomic study (international) and prospective molecular analysis studies (UK only).

Key facts

Study ID

NCT05933889

Run by

Royal Marsden NHS Foundation Trust

People needed

250

Starts

2023-12-19

Expected to finish

2027-08-01

Last updated by the study team

2024-08-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years and older.
• Primary tumour within the oropharynx (defined as tonsil, soft palate, tongue base, lateral and posterior oropharyngeal walls)
• Histologically confirmed squamous cell carcinoma.
• P16 positive or negative tumours
• Index cancer treated with TORS with or without adjuvant therapy.
• Early pT1-T2 stage oropharyngeal SCC
• TORS performed on or before 31st December 2021
• For the exploratory analysis only:
• Ability to consent to molecular analysis study
• Ability to consent to radiomic/ imaging study (as required for international centres)

You may not qualify if…

• Moderate to advanced stage T3-T4 oropharyngeal SCC
• TORS performed for diagnostic, recurrent, or palliative intentions.
• Prior history of head and neck cancer or radiation therapy at any time
• Known distant metastatic disease.
• Nasopharyngeal, thyroid, cutaneous, and non-SCC head and neck cancers.

Where it is running

• The Royal Marsden Hospital NHS Foundation Trust — London, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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