Small Extracellular Vesicles and Insulin Action
Recruiting now · Not applicable
Conditions studied: Obesity, Insulin Resistance, Metabolically Healthy Obesity, Obesity, Metabolically Benign
In brief
The goals of this research study are to: 1) understand why some people with obesity are protected from developing conditions such as type 2 diabetes and cardiovascular disease while others are more likely to develop obesity-related conditions; 2) assess the effect of small extracellular vesicles (sEVs also called exosomes), obtained from human participants, on metabolic function in cultured cells and in mice.
Key facts
- Study ID
- NCT05933707
- Run by
- Washington University School of Medicine
- People needed
- 72
- Starts
- 2023-06-14
- Expected to finish
- 2028-08-31
- Last updated by the study team
- 2026-07-17
Who can join
Age: 25 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Metabolically healthy lean subjects must have a BMI ≥18.5 and ≤24.9 kg/m²; Subjects with obesity must have a BMI ≥30.0 and ≤50.0 kg/m²
- Metabolically healthy lean and people with metabolically healthy obesity must have intrahepatic triglyceride (IHTG) content ≤5%; fasting plasma glucose concentration <100 mg/dl, 2-hr oral glucose tolerance plasma glucose concentration <140 mg/dl, hemoglobin A 1C (HbA1c) ≤5.6% and HOMA-IR <2.5.
- People with metabolically unhealthy obesity must have intrahepatic triglyceride (IHTG) content ≥5.6%; HOMA-IR ≥2.5, and HbA1c 5.7%-6.4%, or fasting plasma glucose concentration ≥100 mg/dl, or 2-hr oral glucose tolerance test (OGTT) plasma glucose concentration ≥140 mg/dl.
You may not qualify if…
- History of diabetes, liver disease other than NAFLD or other serious diseases,
- Consume excessive amounts of alcohol (>21 units/week for men and >14 units/week for women),
- Take medications that could affect the study outcome measures, engage in regular exercise (>120 min/week),
- Are pregnant or lactating
Where it is running
- Washington University School of Medicine — St Louis, Missouri, United States (enrolling)
Full record on ClinicalTrials.gov
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