Effects of Novel E-cigarette Constituents on Adults TCORS 3.0

Recruiting now · Not applicable

Conditions studied: Nicotine Use Disorder

In brief

This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.

Key facts

Study ID

NCT05932745

Run by

Yale University

People needed

66

Starts

2025-06-20

Expected to finish

2026-08-01

Last updated by the study team

2026-06-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years or older
• Able to read and write
• Some current e-cigarette use
• Urine cotinine ≥200ng/ml
• Willing to abstain from tobacco/nicotine use 2 hours prior to sessions

You may not qualify if…

• Current use of non-prescription substances besides nicotine, marijuana, alcohol
• Any significant current medical or psychiatric condition
• Known hypersensitivity to propylene glycol
• Pregnant or lactating females
• Uncontrolled asthma
• Nut/e-liquid flavorant allergy
• Current marijuana (tetrahydrocannabinol) vaping + E-cigarette or vaping use Associated Lung Injury (EVALI) symptoms
• Dislike of menthol flavor

Where it is running

• JB Pierce Lab — New Haven, Connecticut, United States (enrolling)

Full record on ClinicalTrials.gov

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