Yogurt and GI Health

Completed · Not applicable

Conditions studied: Yogurt Intake, Gastrointestinal Immune Function, Gut Microbiome, Gut Health

In brief

The purpose of this research is to assess mucosal immune function responses in the gastrointestinal (GI) tract to twice-daily yogurt consumption. Previous research has shown that dairy yogurt intake can benefit gastrointestinal health. The current study will determine whether a dietary intervention with dairy yogurt will improve mucosal immunity and the gut microbiome.

Key facts

Study ID

NCT05931471

Run by

USDA, Western Human Nutrition Research Center

People needed

32

Starts

2023-09-19

Expected to finish

2024-06-21

Last updated by the study team

2025-03-18

Who can join

Age: 50 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 50 - 75 years
• BMI 18.5 - 39.9 kg/m2

You may not qualify if…

• BMI less than 18.5 or greater than 39.9
• Consumption of fermented foods or probiotics in the past two weeks
• Unwillingness to abstain from non-study fermented foods and probiotics during the trial
• Allergy to cow milk
• Lactose intolerance
• Any dietary restriction limiting or prohibiting consumption of lightly sweetened, vanilla flavored, whole milk yogurt
• Uncomfortable with or unwilling to complete stool sample collections
• Current participation in another research study
• If female,
• Currently pregnant or lactating
• Have had menstrual bleeding in the past 12 months
• Having fewer than 3 bowel movements per week
• Unmanaged hypertension, defined as blood pressure greater than or equal to 140/90 mmHg
• Current diagnosis of:
• Disease that affects the immune system, including HIV/AIDS
• Cancer
• Diabetes
• Asthma with daily medication
• Primary immune deficiency
• Auto-immune disease
• Chronic gastrointestinal disorder (e.g. Crohn's disease, irritable bowel syndrome, colitis, gastric ulcer)
• Current use for 2 weeks or longer of:
• Any drug that affects the immune system, such as immunosuppressants, immune modifying drugs, or corticosteroids (e.g. cortisone, prednisone, methylprednisolone)
• Biologics (e.g. Lantus, Remicade, Rituxan, Humira, Herceptin, Avastin, Lucentis, Enbrel)
• Use of sulfonamides or antibiotics in the past 3 months

Where it is running

• USDA Western Human Nutrition Research Center — Davis, California, United States

Full record on ClinicalTrials.gov

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