CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes
Recruiting now · Phase 3
Conditions studied: End-Stage Kidney Disease, End-Stage Renal Disease
In brief
The investigators aim to determine, using a point-of-care randomized controlled trial design, if hemodialysis patients, who are randomized to metoprolol succinate (a dialyzable, beta-1 selective beta blocker), have an improved cardiovascular outcome compared to those randomized to carvedilol (a non-dialyzable, non-selective beta blocker with alpha-1 antagonist properties). The investigators will also examine intervention practices to identify components that best support engagement and sustainability.
Key facts
- Study ID
- NCT05931276
- Run by
- VA Office of Research and Development
- People needed
- 2540
- Starts
- 2024-05-22
- Expected to finish
- 2028-12-31
- Last updated by the study team
- 2026-01-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- On hemodialysis
- Received one of the following beta blockers through the VA pharmacy: metoprolol (succinate or tartrate), atenolol, labetalol, carvedilol, bisoprolol
You may not qualify if…
- Impaired decision-making capacity
- Patients not receiving carvedilol who have a history of asthma
- known hypersensitivity to any component of either drug
- Provider unwilling to sign a new medication order for a randomized patient
- No surrogate consent will be allowed
Where it is running
- VA Long Beach Healthcare System, Long Beach, CA — Long Beach, California, United States (enrolling)
- North Florida/South Georgia Veterans Health System, Gainesville, FL — Gainesville, Florida, United States (enrolling)
- Atlanta VA Medical and Rehab Center, Decatur, GA — Decatur, Georgia, United States (enrolling)
- Iowa City VA Health Care System, Iowa City, IA — Iowa City, Iowa, United States (enrolling)
- New Mexico VA Health Care System, Albuquerque, NM — Albuquerque, New Mexico, United States (enrolling)
- Minneapolis VA Health Care System, Minneapolis, MN — Minneapolis, Minnesota, United States (enrolling)
- Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE — Omaha, Nebraska, United States (enrolling)
- VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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