No Opioids vs. Minimal Opioids Following Inguinal Hernia Repair

Running, not enrolling · Phase 4

Conditions studied: Postoperative Pain, Inguinal Hernia

In brief

The investigators hypothesize that not prescribing opioids after uncomplicated, outpatient IHR will be non-inferior to prescribing opioids (5 tablets of Oxycodone, 5mg; or surgeon preference for intolerance) with respect to requests for opioid refills. Additionally, the investigators believe there will be no significant difference in postoperative readmission for pain quality of life at 30 days in either group.

Key facts

Study ID

NCT05929937

Run by

Clayton Petro

People needed

904

Starts

2023-07-10

Expected to finish

2027-07-01

Last updated by the study team

2026-03-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients aged 18 years or older
• Patients undergoing elective unilateral or bilateral inguinal hernia repairs
• Patients able to tolerate general anesthesia

You may not qualify if…

• Patients who cannot tolerate general anesthesia,
• Patients who cannot tolerate opioids or NSAIDS,
• Patients on opioids for chronic pain management (defined as near daily use within 90 days),
• Patients who undergo surgeries requiring extensive dissection/hernia sac reduction, or additional procedures,
• Patients requiring inpatient admission postoperatively
• Patients who are not able to understand and sign a written consent form

Where it is running

• MemorialCare — Fountain Valley, California, United States
• Corewell Health — Royal Oak, Michigan, United States
• University Hospitals — Cleveland, Ohio, United States
• Cleveland Clinic Center for Abdominal Core Health — Cleveland, Ohio, United States
• Prisma Health — Greenville, South Carolina, United States
• University of Tennessee Medical Center — Knoxville, Tennessee, United States
• Medical College of Wisconsin — Milwaukee, Wisconsin, United States
• North York General Hospital — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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