Improving Mobility and Function Following Transfemoral Amputation: A Novel Approach to Reverse Volumetric Muscle Loss

Recruiting now · Not applicable

Conditions studied: Traumatic Amputation of Lower Extremity

In brief

The purpose of this study is to investigate the relationship between thigh strength and walking ability and assess if using a blood pressure cuff on the leg improves strength and walking performance.

Key facts

Study ID

NCT05929508

Run by

University of Illinois at Chicago

People needed

30

Starts

2024-04-01

Expected to finish

2027-12-31

Last updated by the study team

2025-11-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• At least 18 years old
• History of lower limb unilateral transfemoral amputation.
• At least two years post lower limb amputation
• Able to ambulate independently without the use of aids (i.e., walking cane).
• Able to walk at least 10 minutes continuously without stopping.
• Has a safe residuum with no open wounds on either the residual or intact limb.
• Has a prosthetic limb with materials that are sound and safe to withstand the mobility requirements of the study.

You may not qualify if…

• Younger than 18 years old.
• Inability to give informed consent.
• Neurological disorder that affects gait.
• Participants with significant metal (greater than one orthopaedic screw) in either the residual limb or the sound/intact limb
• Participants who begin taking medications or change dosage of medications that could affect gait, balance, and cardiovascular function during the course of the study.
• Currently pregnant (or intend to become pregnant while participating in study).
• History of any condition where fatiguing contractions or resisted leg contractions are contraindicated.
• Blood clots in the leg, or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. open wounds in the leg).
• History of uncontrolled hypertension.
• History of heart failure.
• Head injury within the previous 6 months.
• Seizure disorder.
• History of vascular disease.
• History of thrombosis.
• History of sickle cell trait.
• History of genetic disease

Where it is running

• UIC Physical Therapy Faculty Practice — Chicago, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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