Outcomes of Aortic Dissection Repair
Enrolling by invitation
Conditions studied: Type A Aortic Dissection, Ascending Aortic Dissection, Aortic Diseases, Aortic Arch, Aortic Valve Insufficiency, Aortic Root Dissection, Aortic Root Dilatation, Type B Aortic Dissection
In brief
Type A aortic dissection (TAAD) is a potentially life-threatening pathology associated with significant risk of mortality and morbidity. In acute forms of type A aortic dissection (TAAD) mortality is 50% by 24 h and 50% of patients die before reaching a specialist center. Rapid diagnosis and subsequent prompt surgical repair remain the primary goal for these patients. In the last decade it has been observed that improvements in diagnostic techniques, initial management and increased clinical awareness have contributed to a substantial increase in the number of patients benefiting from a prompt diagnosis and undergoing surgery.However, survival after surgical repair has not yet reached optimal follow-ups and is burdened by high in-hospital mortality(16-18%)The main approach to acute type B non-complicated aortic dissection (TBAD) has always been to use medicines to control the patient's heart rate and blood pressure. However, recent findings suggest that a large number of patients treated for acute complicated (TBAAD) and non-complicated TBAD experience aortic complications, such as aneurysmal degeneration, at a later stage.
Key facts
- Study ID
- NCT05927090
- Run by
- Centre Cardiologique du Nord
- People needed
- 1200
- Starts
- 2005-01-01
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-05-19
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients aged > 18 years
- TAAD or intramural hematoma involving the ascending aorta
- Symptoms started within 7 days from surgery
- Primary surgical repair of acute TAAD
- Any other major cardiac surgical procedure concomitant with surgery for TAAD.
You may not qualify if…
- Patients aged < 18 years
- Onset of symptoms > 7 days from surgery
- Prior procedure for TAAD
- Concomitant endocarditis;
- TAAD secondary to blunt or penetrating chest trauma.
Where it is running
- Francesco Nappi — Saint-Denis, France
Full record on ClinicalTrials.gov
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