Chemoreflex and Baroreflex Alterations Causing Postural Tachycardia Syndrome With Orthostatic Hyperpnea and Hypocapnia

Status unconfirmed · Not applicable

Conditions studied: Postural Orthostatic Tachycardia Syndrome, Hypocapnia, Hyperventilation

In brief

Postural tachycardia syndrome (POTS) is the most common chronic cause of postural lightheadedness, and upright confusion afflicting many Americans, mostly young women. Many POTS patients hyperventilate by increasing their depth of breathing that produces tachycardia, alters blood flow and blood pooling in the body and importantly reduces brain blood flow causing "brain fog". In this proposal the investigators will demonstrate in young women that abnormal repeated brief impairment of blood pressure and brain flow just after standing sensitizes the body's oxygen sensor in POTS to respond as if it were in a low oxygen environment causing hyperventilation and its consequences. In this project the investigators will use various drugs that will help to understand the mechanisms that cause POTS in this unique subset of POTS patients who hyperventilate.

Key facts

Study ID: NCT05923840
Run by: New York Medical College
People needed: 30
Starts: 2022-09-23
Expected to finish: 2024-08-31
Last updated by the study team: 2023-06-28

Who can join

Age: 15 and older, up to 39. Sex: female. Healthy volunteers: accepted.

You may qualify if…

The investigators will recruit female POTS cases (N=80) and healthy female control subjects (N=40) aged 15-39 years, matched for BMI. POTS is a disease in which 80-90% are females. Therefore, the investigators will only recruit female POTS patients and controls.

You may not qualify if…

Any subjects with systemic disease or who cannot stop taking prescribed medications for at least 2 weeks prior to study.

Where it is running

NewYork Medical College — Hawthorne, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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