LISH Trial for the Hepatic Flexure and Proximal Transverse Colon Cancer

Recruiting now · Not applicable

Conditions studied: Hepatic Flexure Colon Cancer, Proximal Transverse Colon Cancer

In brief

The goal of this clinical trial is to compare the long-term outcomes of Laparoscopic Ileocecal-Sparing Right Hemicolectomy(LISH) compared to traditional laparoscopic right hemicolectomy(TRH) in the treatment of hepatic flexure colon cancer and proximal transverse colon cancer.

Key facts

Study ID

NCT05923255

Run by

Zhejiang University

People needed

568

Starts

2023-05-14

Expected to finish

2031-05-14

Last updated by the study team

2026-01-27

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 18-75 years old
• ASA classification ≤III
• Colon adenocarcinoma confirmed by endoscopy and pathological biopsy
• Enhanced abdominal CT indicating the primary lesion is located in the hepatic flexure of the colon or proximal transverse colon (proximal 1/3 of the transverse colon)
• Preoperative clinical staging: TanyNanyM0
• Patients able to understand the study protocol, willing to participate in the research, and providing written informed consent

You may not qualify if…

• Preoperative examination indicates synchronous multiple primary colorectal cancers or other diseases requiring bowel segment resection
• Preoperative imaging or intraoperative exploration reveals: 1) tumor involving surrounding organs requiring combined organ resection; 2) presence of distant metastasis; 3) inability to perform R0 resection; 4) fused and fixed lymph nodes at the root of the ileocolic vessels
• Additional radical surgery following Endoscopic Mucosal Resection (EMR) and Endoscopic Submucosal Dissection (ESD) procedures
• History of any other malignant tumor within the last 5 years or familial adenomatous polyposis, except for cured in situ cervical cancer, basal cell carcinoma, papillary thyroid carcinoma, or skin squamous cell carcinoma
• Presence of bowel obstruction, bowel perforation, or intestinal bleeding requiring emergency surgery
• Patients unsuitable for or unable to tolerate laparoscopic surgery
• Pregnant or lactating women
• Patients with a history of psychiatric disorders
• Patients who have received neoadjuvant therapy prior to surgery
• Patients deemed unsuitable for the study by MDT discussion
• Patients unable to understand the study's conditions and objectives, and refusing to sign informed consent.

Where it is running

• Ningbo No.2 Hospital — Ningbo, Zhejiang, China (enrolling)
• Beijing Cancer Hospital — Beijing, Beijing Municipality, China (enrolling)
• Peking Union Medical College Hospital — Beijing, Beijing Municipality, China (enrolling)
• Cancer Hospital Academy of medicine Scenice — Beijing, Beijing Municipality, China (enrolling)
• the First Affiliated Hospital of Chongqing Medical Collage — Chongqing, Chongqing Municipality, China (enrolling)
• Fujian Cancer Hospital — Fuzhou, Fujian, China (enrolling)
• Fujian Hospital Medical Union University — Fuzhou, Fujian, China (enrolling)
• Sir Run Run Shaw Hospital, Zhejiang University School of medicien — Hangzhou, Zhejiang, China (enrolling)
• Jinhua Municipal Central Hospital — Jinhua, Zhejiang, China (enrolling)
• the First Affiliated Hospital of Bengbu Medical Collage — Bengbu, Anhui, China (enrolling)
• Guangdong Second Provincial General Hospital — Guangzhou, Guangdong, China (enrolling)
• The Sixth Affiliated Hospital of Sun Yat-sen University — Guangzhou, Guangdong, China (enrolling)
• Union Hospital, Tongji Medical College, Huazhong University of Science and Technolog — Wuhan, Hubei, China (enrolling)
• People's Hospital of Hunan Province — Changsha, Hunan, China (enrolling)
• Nanjing Drum Tower Hospital — Nanjing, Jiangsu, China (enrolling)
• The Second Affiliated Hospital of Nanchang University — Nanchang, Jiangxi, China (enrolling)
• Shandong Cancer Hospital — Jinan, Shandong, China (enrolling)
• The Affiliated Hospital of Qingdao University — Qingdao, Shandong, China (enrolling)
• Changhai Hospital of Shanghai — Shanghai, Shanghai Municipality, China (enrolling)
• Fudan University Shanghai Cancer Center — Shanghai, Shanghai Municipality, China (enrolling)
• Ruijin Hospital Affiliated of The Shanghai Jiao Tong University Medical School — Shanghai, Shanghai Municipality, China (enrolling)
• The first affiliated hospital of xi'an jiaotong university — Xi’an, Shanxi, China (enrolling)
• West China Hospital of Sichuang University — Chengdu, Sichuan, China (enrolling)
• The Cancer Hospital Affiliated of The Xingjiang University Medical School — Xinjiang, Xinjiang, China (enrolling)
• Yunnan Cancer Hospital — Kunming, Yunnan, China (enrolling)

Full record on ClinicalTrials.gov

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