Comprehensive Imaging Exam of Convalesced COVID-19 Patients

Completed · Not applicable

Conditions studied: COVID-19, COVID Long-Haul

In brief

COVID-19 is a systemic inflammatory disease involving many organs including the lungs, vascular system liver and myocardium that lead to severe pathologies. Patients with severe cardiopulmonary symptoms usually require weeks to months to fully recover. Studies of clinical and subclinical impairments of COVID-19 patients are important for medical practice and public health as well as providing pathogenic insight to the viral infection and secondary immune response. Chronic damage of vital organs and systems, and the potential long-term effects is of serious concern. In this study the investigators plan to quantify and characterize chronic consequences of COVID-19 in individuals who receive similar medical care related to disease severity and duration in a single health care system. Using state-of-the-art Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) technology, we will study the pathology in major organ systems in comparison to matched controls. The results of this study may facilitate measures to prevent, detect, and manage complications from COVID-19 infections.

Key facts

Study ID

NCT05920616

Run by

Johns Hopkins University

People needed

206

Starts

2020-10-14

Expected to finish

2026-05-15

Last updated by the study team

2026-06-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age: 18+
• Diagnosed with COVID-19 at any point starting March 2020.
• Subgroup A: hospitalized due to COVID-19 infection
• Subgroup B: non-hospitalized

You may not qualify if…

• Known allergy to either gadolinium or iodine based contrast agents
• Glomerular Filtration Rate (GFR) <45 mL/min (using the Cockcroft-Gault formula)
• Pregnancy
• Internal electrical devices, such as cochlear implant, spinal cord stimulator, pacemaker, or defibrillator
• Atrial fibrillation, uncontrolled tachyarrhythmia or advanced atrioventricular block (2nd or 3rd degree) at time of imaging
• Evidence of severe symptomatic heart failure (NYHA Class III or IV) at the time of imaging
• Other acute illness
• Ongoing mechanical ventilation related to hospitalization for COVID-19 related illness
• Presence of any other history or condition that the investigator feels would be problematic
• Weight exceeding 300 lbs (MRI table weight restrictions)
• Severe claustrophobia

Where it is running

• Johns Hopkins School of Medicine — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.