Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"

Recruiting now · Not applicable

Conditions studied: Heart Failure, Cardiovascular Diseases

In brief

This is an international prospective, multicentre, unblinded, randomised-controlled trial. The primary aim is to assess a targeted screening strategy to detect undiagnosed heart failure in high-risk patients.

Key facts

Study ID

NCT05919342

Run by

NHS Greater Glasgow and Clyde

People needed

3904

Starts

2022-12-22

Expected to finish

2032-12-21

Last updated by the study team

2023-08-04

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female ≥40 years of age
• Informed consent
• Two or more of the following risk factors for heart failure:
• Coronary artery disease (either a previous documented type 1 myocardial infarction or coronary artery bypass grafting or percutaneous coronary intervention or documented stenosis of an epicardial coronary artery [50% left main stem or >70% left anterior descending, circumflex or right coronary artery])
• An established diagnosis of diabetes (type 1 or type 2)
• Persistent or permanent atrial fibrillation (not paroxysmal atrial fibrillation)
• Previous ischemic or embolic stroke
• Peripheral arterial disease (previous surgical or percutaneous revascularisation or a documented stenosis greater than 50% of a major peripheral arterial vessel).
• Chronic kidney disease (defined as an estimated glomerular filtration rate <60mL/min/1.73m2 or eGFR 60-90mL/min/1.73m2 and UACR >300mg/g).
• Regular loop diuretic use (any dose at any dosing interval) for >30 days.
• COPD (evidenced by one of the following: PFTs showing airway obstruction, diagnosis by respiratory physician, CT scan reporting presence of emphysema or treatment with national guideline advocated COPD therapy).

You may not qualify if…

• Inability to give informed consent e.g., due to significant cognitive impairment
• Previous documented diagnosis of heart failure
• Current renal replacement therapy
• Anyone who, in the investigators' opinion, is not suitable to participate in the trial for other reasons e.g., a diagnosis which may compromise survival over the study period

Where it is running

• University of Glasgow — Glasgow, Scotland, United Kingdom (enrolling)
• University of British Columbia — Vancouver, British Columbia, Canada
• University of Montreal — Montreal, Quebec, Canada
• Cleveland Clinic — Cleveland, Ohio, United States
• Karolinska University Hospital — Stockholm, Sweden
• Uppsala University — Uppsala, Sweden
• Rigshospitalet, Copenhagen University Hospital — Copenhagen, Denmark

Full record on ClinicalTrials.gov

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