Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients

Recruiting now · Not applicable

Conditions studied: Obesity, Morbid, Extubation Failure

In brief

Around 20% of the obese patients with higher body mass index (BMI) who are taken off the breathing tube and breathing machine (ventilator) end up needing it back to support breathing. The re-application of breathing tube is associated with poor outcomes, including high risk of pneumonia, longer hospital stays, and death. The purpose of this study is to assess if prophylactic use of noninvasive breathing support after removing the breathing tube lowers the chance of needing the breathing tube again.

Key facts

Study ID

NCT05918575

Run by

Rush University Medical Center

People needed

250

Starts

2023-07-10

Expected to finish

2028-12-01

Last updated by the study team

2026-08-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult, age ≥ 18 years old
• Receiving invasive mechanical ventilation for ≥24 hours
• BMI ≥40 kg/m2
• Undergoing planned extubation per treating team
• Arterial pH ≥7.35 or venous pH ≥ 7.31 within 30 mins of spontaneous breathing trial (SBT)

You may not qualify if…

• Pregnant
• Use of extra-corporeal membrane oxygenation
• Chronic tracheostomy in place
• Unplanned or accidental extubation
• Terminal/compassionate extubation
• Contraindication to NIV use
• Intubated because of an acute exacerbation of COPD
• Underlying neuromuscular disease
• No reintubation requested by patient/family
• Documented/known history of chronic hypercapnic respiratory failure on home NIV (including bilevel PAP).
• Enrolled in any other outcome study
• Treating clinician feels that HFNC or NIV are either mandatory or contraindicated for a given patient

Where it is running

• Rush University Medical Center — Chicago, Illinois, United States (enrolling)
• McGovern Medical School, The University of Texas Health Science Center — Houston, Texas, United States (enrolling)
• Medical College of Wisconsin — Milwaukee, Wisconsin, United States (enrolling)
• Hospital Civil Fray Antonio Alcalde — Guadalajara, Jalisco, Mexico (enrolling)
• Central DuPage Hospital — Winfield, Illinois, United States

Full record on ClinicalTrials.gov

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