Bone in CKD Alkali Response (BICARb Pilot Trial)

Stopped early · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Chronic Kidney Diseases, Bone Loss

In brief

The goal of this clinical trial is to test whether potassium citrate improves skeletal health in adults and children with chronic kidney disease. The main questions it aims to answer are: * To evaluate effects of potassium citrate treatment on bone quality and strength. * To evaluate mechanism(s) underlying the effects of potassium citrate on skeletal health. Participants will be asked to: * provide blood, urine and answer questions about health and diet three times during an 8 months period * undergo advanced bone imaging with high resolution-peripheral quantitative CT scan twice during 8 months * take study pills for 4-6 weeks at the beginning of the study to ensure safety * take either potassium citrate or placebo for 6 months during the blinded portion of the study As part of the study, there will be a run-in period followed by the placebo-controlled randomized clinical trial. Researchers will compare the bone imaging between the potassium citrate and the placebo groups at the end of the study.

Key facts

Study ID
NCT05918029
Run by
Albert Einstein College of Medicine
People needed
6
Starts
2024-08-15
Expected to finish
2025-05-16
Last updated by the study team
2026-07-28

Who can join

Age: 5 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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