Metformin for the Treatment of Microvascular Dysfunction After Gestational Diabetes

Recruiting now · Early Phase 1 · Has a placebo group

Conditions studied: Gestational Diabetes

In brief

The purpose of this investigation is to examine the mechanisms mediating vascular dysfunction in women who have had gestational diabetes and how metformin may be a valuable treatment tool to improve microvascular function in these women before the onset of disease.

Key facts

Study ID

NCT05917587

Run by

Anna Stanhewicz, PhD

People needed

30

Starts

2024-09-11

Expected to finish

2028-06-30

Last updated by the study team

2025-05-13

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• ≥12 weeks and ≤5 years postpartum
• history of GDM or healthy pregnancy

You may not qualify if…

• prediabetes or diabetes (HbA1c ≥5.7%)
• current tobacco use
• cardiovascular or metabolic disease
• cardiovascular or metabolic medication
• history of hypertension during pregnancy
• current pregnancy

Where it is running

• University of Iowa — Iowa City, Iowa, United States (enrolling)

Full record on ClinicalTrials.gov

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