Impact of Forced Diuresis on the Residual Fragment Rate After Flexible Ureteroscopy for Destruction of Kidney Stones With Laser
Recruiting now · Phase 3
Conditions studied: Kidney Stone
In brief
In view of the positive results of the numerous studies conducted on forced diuresis after extra-corporeal lithotripsy, the investigators chose to evaluate forced diuresis by injection of Furosemide associated with intravenous hydration, which has never before been the subject of a specific analysis.
Key facts
- Study ID
- NCT05916963
- Run by
- University Hospital, Tours
- People needed
- 374
- Starts
- 2024-01-04
- Expected to finish
- 2026-04-03
- Last updated by the study team
- 2025-11-24
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients ≥ 18 years old and < 80 years old
- With the need to perform a flexible ureteroscopy with destruction of the kidney stones with laser
- Participants covered by or entitled to social security
- Written informed consent obtained from the participant
- Ability for participant to comply with the requirements of the study
You may not qualify if…
- Persons covered by articles L1121-5 to L1121-8 of the CSP (corresponding to all protected persons: pregnant women, parturients, nursing mothers, persons deprived of their liberty by judicial or administrative decision, minors, and persons subject to a legal protection measure: guardianship or trusteeship)
- Contra-indication to Furosemide:
- Hyper-sensitivity to the active substance or one of the excipients
- Hyper-sensitivity to Sulfonamide
- Renal failure with oligo-anuria refractory to Furosemide
- Hypokalemia < 3,5 mmol/L
- Severe hyponatremia
- Hypovolemia with or without hypotension or dehydration
- Ongoing hepatitis, hepatic insufficiency severe and hepatic encephalopathy
- Patient having Furosemide as usual treatment
- Patient requiring an injection of Aminoside or Vancomycin before or during the procedure
- Participation in other interventional research with an investigational drug or medical device
Where it is running
- CHU d'Angers — Angers, France (enrolling)
- Hospices Civils de Lyon — Lyon, France (enrolling)
- CHU de Nice — Nice, France (enrolling)
- CHU de Nîmes — Nîmes, France (enrolling)
- CHU de Rennes — Rennes, France (enrolling)
- CHU de Rouen — Rouen, France (enrolling)
- CHU de Toulouse — Toulouse, France (enrolling)
- Clinique La Croix du Sud — Toulouse, France (enrolling)
- CHRU de Tours — Tours, France (enrolling)
Full record on ClinicalTrials.gov
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