Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response
Recruiting now · Phase 1 · Has a placebo group
Conditions studied: Depressive Disorder, Major, Post Traumatic Stress Disorder
In brief
The proposed study will assess the combined effect of perampanel and ketamine on the anti-depressant response in individuals with treatment resistant depression. The purpose of this study is to test the hypothesis that stimulation of Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid receptors (AMPAR) is critical to the anti-depressant response of ketamine.
Key facts
- Study ID
- NCT05915013
- Run by
- Yale University
- People needed
- 50
- Starts
- 2023-09-07
- Expected to finish
- 2032-12-01
- Last updated by the study team
- 2026-05-06
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Yale University — New Haven, Connecticut, United States (enrolling)
Full record on ClinicalTrials.gov
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