NC Testing in LC & POTS

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Postural Orthostatic Tachycardia Syndrome, Post Acute Sequelae of SARS CoV 2 Infection

In brief

Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or "Long COVID") experience cognitive dysfunction. The investigators will test the hypothesis that 999 mL of IV saline will improve cognitive function in patients with POTS and Long COVID compared to placebo (50 mL of saline).

Key facts

Study ID

NCT05914649

Run by

University of Calgary

People needed

100

Starts

2024-09-19

Expected to finish

2030-12-31

Last updated by the study team

2026-05-07

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients with diagnosis of Long COVID
• SARS-COV2 test positive
• Symptoms > 12 weeks post COVID
• Subjective complaint of 'brain fog" or cognitive dysfunction
• Patients with diagnosis of Postural Orthostatic Syndrome (POTS) from the Calgary Autonomic Investigation and Management Clinic
• Subjective complaint of 'brain fog" or cognitive impairment
• Healthy participants
• Without POTS or "brain fog"
• Age 18 to 60 years
• Female and Male
• Able to give an informed consent

You may not qualify if…

• Patients with overt causes for POTS (e.g., dehydration, prolonged bed rest)
• An inability to safely withdraw from medicine(s) that could make test interpretation difficult and impossible.
• Other factors which are in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies or an unpredictable schedule.
• Unable to give an informed consent.

Where it is running

• University of Calgary — Calgary, Alberta, Canada (enrolling)

Full record on ClinicalTrials.gov

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