Combined Respiratory Training in Persons With ALS
Recruiting now · Not applicable
Conditions studied: ALS, Respiratory Insufficiency, Dysphagia
In brief
The goal of this interventional trial is to learn about lung volume recruitment (LVR) and expiratory muscle strength training (EMST) in a total of up to 39 patients diagnosed with ALS. The following aims will be addressed: 1. Determine the impact of combined LVR and EMST on cough strength and respiratory function in individuals with ALS. 2. Determine the impact of combined LVR and EMST on patient-reported dyspnea and bulbar impairment. 3. Describe the effect of combined LVR and EMST on patient- and caregiver reported burden and quality of life.
Key facts
- Study ID
- NCT05913882
- Run by
- Nova Southeastern University
- People needed
- 34
- Starts
- 2023-08-22
- Expected to finish
- 2026-09-30
- Last updated by the study team
- 2025-12-23
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- A diagnosis of probable or definite ALS in accordance with the Revisited El-Escorial Criteria.
- Disease duration from symptom onset of ≤ 2 years,
- Lung volume recruitment and expiratory muscle strength training naïve,
- Reduced peak cough flow (% predicted for age and gender).
You may not qualify if…
- History of stroke, head and neck cancer or other concomitant disorder that might contribute to dysphagia or respiratory impairment.
- Use of prescription cough assist or non-invasive volume ventilation devices.
- Enrollment in another research investigation that might impact cough or respiratory function.
- Diagnosis of frontotemporal dementia or advanced cognitive impairment.
- Tracheostomy placement/Use of invasive mechanical ventilation.
- Contraindications for respiratory training (i.e., history of pneumothorax, severe chronic obstructive pulmonary disease).
Where it is running
- Nova Southeastern University — Fort Lauderdale, Florida, United States (enrolling)
Full record on ClinicalTrials.gov
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