Exercise to Augment TMS in Those With Treatment Resistant Depression

Completed · Not applicable

Conditions studied: Treatment Resistant Depression

In brief

Given the growing evidence that aerobic increases cortical excitability and promotes neuroplasticity, the scientific premise for its potential priming effect on the brain is strong. Combining AE with rTMS may produce a neural environment optimized for a robust physiological effect of rTMS, thereby leading to improved depression outcomes. With positive findings, this study would provide preliminary support for an innovative, safe and feasible approach for improving outcomes for this significant public health problem.

Key facts

Study ID

NCT05913401

Run by

Butler Hospital

People needed

26

Starts

2024-02-01

Expected to finish

2025-12-31

Last updated by the study team

2026-06-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• adult outpatients (age 18 and above) who are already approved to receive standard TMS therapy through the Butler Hospital TMS clinic.
• able to safely engage in moderate-intensity aerobic exercise (determined by a study physician)

You may not qualify if…

• Currently pregnant or plans to become pregnant in the next 6 weeks

Where it is running

• Butler Hospital — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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