Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery

Completed · Not applicable · Has a placebo group

Conditions studied: Anosmia, Skull Base Neoplasms

In brief

The investigators hypothesize that patients undergoing endoscopic endonasal skull base surgery experience clinically meaningful and modifiable disruptions in postoperative chemosensory function and quality of life, and the investigators further hypothesize that olfactory training in the postoperative period may significantly hasten normalization of patients' chemosensory perturbations. This tailored prospective study seeks to fulfill a significant gap in the understanding of the characteristics, implications, and treatment options for postoperative olfactory and gustatory impairment following endoscopic endonasal skull base surgery.

Key facts

Study ID

NCT05912881

Run by

Johns Hopkins University

People needed

41

Starts

2023-02-01

Expected to finish

2026-01-01

Last updated by the study team

2026-02-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• English Speaking
• preoperative diagnosis of benign sellar or parasellar skull base pathology

You may not qualify if…

• preoperative diagnosis of malignant sellar or parasellar skull base pathology
• history of endoscopic sinus surgery
• history of skull base surgery
• history of radiation therapy or other local treatments for the management of facial, sinonasal, or cranial pathologies
• history of chronic rhinosinusitis
• history of neurocognitive disorder
• history of intrinsic chemosensory pathology
• history of cardiac pacemaker
• history of gastrectomy

Where it is running

• Johns Hopkins Medicine — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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