Investigating Genetic Status in Patients Presenting to Clinic

Recruiting now

Conditions studied: Dementia, Frontotemporal, Alzheimer Dementia (AD), Lewy Body Dementia (LBD)

In brief

The causes of neurodegenerative dementias such as Frontotemporal Dementia, Lewy Body Disease and Alzheimer's disease are still largely unknown. While the contribution of some genetic mutations and polymorphisms is associated with autosomal dominant patterns of inheritance of these dementias, in many cases, the specific causative mutation in these families is not yet identified. Further, in many patients, polygenic risk is thought to give rise to pathophysiologic changes, but which specific genes affect risk are largely yet unknown. By examining genotypes in patients that present to our Cognitive Neurology and Alzheimer's Research Clinic with suspected or confirmed neurodegenerative dementia, or have a history of a familial dementia, we aim to help identify and characterize genetic mutations or polymorphisms that give rise to neurodegenerative diseases.

Key facts

Study ID: NCT05911932
Run by: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
People needed: 1000
Starts: 2023-10-20
Expected to finish: 2043-08-01
Last updated by the study team: 2025-03-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Persons presenting to the cognitive clinic with a neurodegenerative disorder (for example, AD, FTD, LBD, ALSP, and related conditions);
Biological family members of someone diagnosed with a neurodegenerative disorder, presenting to clinic;
Age 18+ years old;
Consenting to a blood draw.

You may not qualify if…

Persons declining / unwilling / not able to have a blood draw.

Where it is running

Parkwood Institute — London, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.