Treatment With Endovascular Intervention for STroke Patients With Existing Disability

Recruiting now

Conditions studied: Stroke, Stroke, Acute, Stroke, Ischemic

In brief

TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a moderate-to-severe disability prior to their stroke.

Key facts

Study ID

NCT05911568

Run by

University of Cincinnati

People needed

1060

Starts

2023-11-16

Expected to finish

2028-04-15

Last updated by the study team

2026-04-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients (≥18 years)
• Moderate-to-severe pre-stroke functional disability, defined as mRS 3-4, for at least 3 months prior to stroke onset
• Presenting to study hospital within 24 hours of last known well time
• Diagnosis of acute ischemic stroke
• Intracranial causative occlusion of the internal carotid artery or the M1 or dominant M2 segments of the middle cerebral artery visualized on the baseline CT(or MR) angiogram
• Presenting CT Alberta Stroke Program Early CT (ASPECT) score ≥3 or MRI ASPECT score ≥4
• Presenting NIH Stroke Scale score ≥6
• Informed consent from patient if competent or from legally authorized representative

You may not qualify if…

• Known diagnosis of a terminal cancer or terminal illness at the time of stroke
• Assessment of pre-stroke functional status cannot be performed during the hospital stay
• Pre-stroke disability deemed temporary in the investigator's opinion (for example, recovering from a general medical illness or traumatic bodily injury)

Where it is running

• HonorHealth — Phoenix, Arizona, United States (enrolling)
• Kaiser Permanente Los Angeles Medical Center — Los Angeles, California, United States (enrolling)
• University of California at Los Angeles — Los Angeles, California, United States (enrolling)
• Standford — Palo Alto, California, United States (enrolling)
• University of Cincinnati San Diego — San Diego, California, United States (enrolling)
• Swedish Medical Center — Englewood, Colorado, United States (enrolling)
• Hartford Health Hospital — Hartford, Connecticut, United States (enrolling)
• Yale University — New Haven, Connecticut, United States (enrolling)
• University of Miami — Miami, Florida, United States (enrolling)
• Emory University — Atlanta, Georgia, United States (enrolling)
• University of Chicago — Chicago, Illinois, United States (enrolling)
• University of Louisville — Louisville, Kentucky, United States (enrolling)
• Boston Medical Center — Boston, Massachusetts, United States (enrolling)
• Barnes Jewish Hospital — Saint Loius, Missouri, United States (enrolling)
• New York University — Brooklyn, New York, United States (enrolling)
• Icahn School of Medicine at Mount Sinai — New York, New York, United States (enrolling)
• Columbia University — New York, New York, United States (enrolling)
• University of Cincinnati Medical Center — Cincinnati, Ohio, United States (enrolling)
• Providence St. Vincent Medical Center — Portland, Oregon, United States (enrolling)
• University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States (enrolling)
• Baptist Memorial Hospital — Memphis, Tennessee, United States (enrolling)
• Vanderbilt University Medical Center — Nashville, Tennessee, United States (enrolling)
• University of Texas at Austin — Austin, Texas, United States (enrolling)
• University of Washington — Seattle, Washington, United States (enrolling)
• West Virginia University — Morgantown, West Virginia, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.