Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

Recruiting now

Conditions studied: Stroke, Intracranial Atherosclerotic Stenosis (ICAS)

In brief

CAPTIVA-MRI is an observational multimodal MR imaging study that is ancillary to the CAPTIVA trial \[a 3-arm, double-blind Phase III trial conducted at approximately 115 StrokeNet sites randomizing patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban.\] The primary goal of this ancillary study is to determine if MRI biomarkers can potentially identify ICAS patients who fail best medical management. The CAPTIVA-MRI study leverages the CAPTIVA trial design and implementation to capture information that will inform and facilitate the next generation of ICAS trials and the management of patients with ICAS.

Key facts

Study ID

NCT05907629

Run by

Yale University

People needed

300

Starts

2024-06-24

Expected to finish

2029-03-31

Last updated by the study team

2026-07-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Enrollment in the CAPTIVA trial: nondisabling symptomatic ischemic infarct stroke within 30 days secondary to 70-99% stenosis of the intracranial ICA, MCA, BA or VA
• Ability to obtain baseline study MRI within 14 days of CAPTIVA enrollmen

You may not qualify if…

• Unable or unwilling to undergo MRI, including pacemaker or other MRI contraindications per American College of Radiology guidelines62
• Gadolinium contrast allergy or acute or chronic kidney disease with eGFR<30 ml/min/1.73m2

Where it is running

• UVA Medical Center — Charlottesville, Virginia, United States (enrolling)
• Yale New Haven Hospital — New Haven, Connecticut, United States (enrolling)
• MedStar Washington Hospital Center — Washington D.C., District of Columbia, United States (enrolling)
• Baptist Medical Center Jacksonville — Jacksonville, Florida, United States (enrolling)
• Jackson Memorial Hospital, Miami — Miami, Florida, United States (enrolling)
• University of Illinois Hospital — Chicago, Illinois, United States (enrolling)
• University of Chicago Medical Center — Chicago, Illinois, United States (enrolling)
• Barnes Jewish Hospital — St Louis, Missouri, United States (enrolling)
• Buffalo General Medical Center — Buffalo, New York, United States (enrolling)
• North Shore University Hospita — Manhasset, New York, United States (enrolling)
• University of Cincinnati Medical Center — Cincinnati, Ohio, United States (enrolling)
• UH Cleveland Medical Center — Cleveland, Ohio, United States (enrolling)
• University of Texas Medical Branch — Galveston, Texas, United States (enrolling)
• University of Alabama Hospital — Birmingham, Alabama, United States (enrolling)
• Mercy St. Vincent Medical Center — Toledo, Ohio, United States
• University of Colorado Hospital — Aurora, Colorado, United States
• Hartford Hospital — Hartford, Connecticut, United States
• Prisma Health Richland Hospital — Columbia, South Carolina, United States
• NYP Columbia University Medical Center — New York, New York, United States
• Carolinas Medical Center — Charlotte, North Carolina, United States
• Duke University Hospital — Durham, North Carolina, United States
• Cleveland Clinic Tradition Hospital — Port Saint Lucie, Florida, United States
• SIH Memorial Hospital of Carbondale — Carbondale, Illinois, United States
• Cleveland Clinic Akron General — Akron, Ohio, United States
• Covenant Medical Center — Lubbock, Texas, United States

Full record on ClinicalTrials.gov

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