Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy

Recruiting now

Conditions studied: Treatment Resistant Depression

In brief

Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.

Key facts

Study ID

NCT05905705

Run by

Washington University School of Medicine

People needed

50

Starts

2023-03-07

Expected to finish

2027-07-31

Last updated by the study team

2026-03-12

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Referral for initial ECT index course for Treatment-Resistant Depression (TRD), unipolar major depressive disorder or bipolar depression. Historic failure of response or remission to at least two antidepressant medications of sufficient dose and duration will be used for TRD diagnostic.

You may not qualify if…

• Diagnoses of schizophrenia or schizoaffective disorders.
• Subjects who are unable to tolerate the Dreem device for sleep recordings will be excluded from the study.

Where it is running

• Washington University School of Medicine/Barnes-Jewish Hospital — St Louis, Missouri, United States (enrolling)

Full record on ClinicalTrials.gov

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