SVRd for the Treatment of Newly Diagnosed Multiple Myeloma Patients Presenting With Extramedullary Disease

Recruiting now · Phase 2

Conditions studied: Multiple Myeloma

In brief

The purpose of this study is to evaluate the efficacy and safety of SVRd in NDMM patients presenting with extramedullary disease.

Key facts

Study ID: NCT05900882
Run by: The First Affiliated Hospital with Nanjing Medical University
People needed: 35
Starts: 2022-07-15
Expected to finish: 2025-08-30
Last updated by the study team: 2025-08-17

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Men and women aged with18-75 years old.
Confirmed diagnosis of Multiple Myeloma(MM) (IMWG consensus guidelines)
Newly diagnosed patients presenting with extramedullary disease (EMD) including solely paraskeletal plasmacytoma, plasmacytoma of soft tissue and other special sites detected by physical exam and confirmed by CT/MRI/PET-CT and/or biopsy (≥2cm).
ANC≥1.0*10\^9/L, HGB≥75*10\^9/L, PLT≥50*10\^9/L (≥50% of bone marrow nucleated cells are plasma cells).
Patients whose expecting survival time will be more than 3 months.
Without active infectious disease.
Female patients of child-bearing potential must have a negative serum pregnancy test at screening and all patients agree to use two reliable methods of contraception for six months after their last dose of medication.
Willingness and ability to comply with scheduled visits, treatment plans, laboratory tests and other study procedures.
Each patient must sign an informed consent form (ICF) indicating that he or she understands the purpose of and procedures required for the study and are willing to participate in the study.

You may not qualify if…

Patients who have HBV, HCV, and other acquired and congenital immunodeficiency diseases.
Patients who have grade 2 or higher of peripheral neuropathy or neuralgia according to the definition of NCI CTCAE version 4.0.
Plasma cell leukemia.
Serious thrombotic events.
Active, unstable cardiovascular dysfunction: a. symptomatic ischemia; b. Uncontrolled, clinically significant conduction abnormalities (except antiarrhythmic ventricular tachycardia), but patients with first-degree atrioventricular block or asymptomatic left anterior bundle/right fascicular block cannot be excluded. c. New York Heart Association (NYHA) Class III - IV or left ventricular ejection fraction (LVEF) <40%; d. Myocardial infarction Within 3 months before C1D1.
Significant hepatic dysfunction (ALT and AST ≥ 3 times the upper limit of normal (ULN)).
Serum bilirubin≥1.5 × ULN.
creatinine clearance <30 ml/min.
History of active malignancy during the past 5 years with the exception of basal carcinoma of the skin or stage 0 cervical carcinoma.
Previous major operation within 30 days before C1D1.
Patients who have epilepsy, dementia requiring medication, or other mental disorders who are unable to understand or adhere to the study protocol.
According to the study protocol or in the opinion of the investigator,serious physical or mental illness that is likely to interfere with the study procedures/results.
Any psychological, familial, sociological and geographical condition potentially hampering compliance with the study protocol and follow-up schedule.
Current participation in another clinical trial.
Pregnant or lactating women.
Patients with other commodities that the investigators considered not suitable for the enrollment.

Where it is running

The First Affiliated Hospital of Nanjing Medical University — Nanjing, Jiangsu, China (enrolling)
Changzhou Second People's Hospital — Changzhou, Jiangsu, China
Nanjing First People's Hospital — Nanjing, Jiangsu, China
Affiliated Hospital of Nantong University — Nantong, Jiangsu, China
Taizhou People's Hospital — Taizhou, Jiangsu, China
Yancheng First People's Hospital — Yancheng, Jiangsu, China

Full record on ClinicalTrials.gov

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