Immune Function and the Progression to T1D

Recruiting now

Conditions studied: Type 1 Diabetes

In brief

To elucidate the mechanisms by which type 1 diabetes-associated genes; IFIH1, TYK2, IKZF4, as well as total genetic risk, impart functional immunoregulatory abnormalities that result in expansion of self-reactive adaptive immune cells, defective regulatory/effector mechanisms in T cells, inflammatory antigen presenting cells, and abnormal immune function in T cells and B cells.

Key facts

Study ID

NCT05899439

Run by

University of Florida

People needed

2800

Starts

2005-01-01

Expected to finish

2085-01-01

Last updated by the study team

2026-04-09

Who can join

Age: any, up to 100. Sex: any. Healthy volunteers: accepted.

Where it is running

• Kieran McGrail — Gainesville, Florida, United States (enrolling)
• The Ohio State University — Columbus, Ohio, United States (enrolling)
• Baylor College of Medicine, Center for Research Advancement - Texas Children's Hospital — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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